The 2-Minute Rule for Bet on Sports
The 2-Minute Rule for Bet on Sports
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DNA ligases seal five′-PO4 and three′-OH polynucleotide finishes by using 3 nucleotidyl transfer ways involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are vital guardians of genomic integrity, and ligase dysfunction underlies human genetic disorder syndromes. Crystal constructions of DNA ligases certain to nucleotide and nucleic acid substrates have illuminated how ligase reaction chemistry is catalyzed, how ligases figure out damaged DNA finishes, And just how protein domain movements and active-site remodeling are accustomed to choreograph the top-joining pathway.
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